Debio 0617B

MedChem Express

Debio 0617B [1332329-27-7]

10

1332329-27-7

Research Use Only

C28H23ClF3N7O2

581.98

Debio 0617B, a multi-kinase inhibitor, reduces maintenance and self-renewal of primary human AML CD34 + stem/progenitor cells. Debio 0617B has a unique profile targeting key kinases upstream of STAT3/STAT5 signaling such as JAK, SRC, ABL, and class III/V receptor tyrosine kinases (TKs). Debio 0617B has documented efficacy in STAT3-driven solid tumors [1] .

O=C(C1=NC=CC(C(F)(F)F)=C1)NC2=CC=C(Cl)C(N3CCC4=NC(NC5=CC=C(C(NC)=O)C=C5)=NC=C4C3)=C2

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