DEDAF peptide

GeneTex

DEDAF peptide

9

The peptide is used for blocking the activity of anti-DEDAF (cat. No 5976). It usually blocks the antibody activity completely in Western blot by incubating the peptide with equal volume of antibody for 30 min at 37C.

Neutralisation/Blocking

Research Use Only

0.20 mg/ml

Unconjugated

Cell death signal are transduced by Death Domain (DD), Death Effector Domain (DED), and Caspase Recruitment Domain (CARD) containing molecules. A novel protein that interacts with DED of caspase-8 and -10, and FADD was recently identified and designated DEDAF (for DED associated factor). DEDAF is identical to the transcriptional repressor RYBP. DEDAF interacts with FADD and augments the formation of CD95/FADD/caspase-8 complexes at the cytoplasm. DEDAF also interacts with DED-containing DNA binding protein (DEDD) in the nucleus, indicating it is involved in the regulation of both cytoplasmic and nuclear events of apoptosis.

-20°C

12352202