DEF6 (C2) Antibody, Rabbit Polyclonal

Biorbyt

DEF6 antibody

16

Western Blot

WB:1:1000-1:3000 WB

Research Use Only

Polyclonal

Unconjugated

Def6

differentially expressed in FDCP 6

2410003F05Rik, 6430538D02Rik, Ibp, Slat, Slat2, Slat6, differentially expressed in FDCP 6, DEF-6, IRF-4-binding protein, IRF4-binding protein, SWAP-70-like adapter of T-cells

Rabbit

Differentially expressed in FDCP 6

Rabbit polyclonal to DEF6.Differentially expressed in FDCP 6 (DEF6) is also known as SWAP-70-like adapter of T-cells (SLAT), which is a phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF). DEF6 plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42, and regulates cell morphology in cooperation with activated RAC1. DEF6 also plays a role in Th2 (T helper cells) development and/or activation by interfering with ZAP70 signaling. DEF6 is required for optimal T-cell effector function, lymphocyte homeostasis and the prevention of sytemic autoimmunity. Defects in DEF6 results in spontaneous development of a lupus-like syndrome in aging female mice.

-20°C

12352203