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ProductsBack/DEF6 antibody

DEF6 antibody

Research Use Only
ORB67083
Biorbyt
ApplicationsWestern Blot
Product group Antibodies
ReactivityMouse
TargetDef6
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Overview

  • Supplier
    Biorbyt
  • Product Name
    DEF6 antibody
  • Delivery Days Customer
    16
  • Applications
    Western Blot
  • Applications Supplier
    WB:1:1000-1:3000 WB
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID23853
  • Target name
    Def6
  • Target description
    differentially expressed in FDCP 6
  • Target synonyms
    2410003F05Rik; 6430538D02Rik; AV094905; DEF-6; differentially expressed in FDCP 6; I; Ibp; IRF-4-binding protein; IRF4-binding protein; S; Slat; Slat2; Slat6; SWAP-70-like adapter of T-cells
  • Host
    Rabbit
  • Protein IDQ8C2K1
  • Protein Name
    Differentially expressed in FDCP 6
  • Scientific Description
    Rabbit polyclonal to DEF6.Differentially expressed in FDCP 6 (DEF6) is also known as SWAP-70-like adapter of T-cells (SLAT), which is a phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF). DEF6 plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42, and regulates cell morphology in cooperation with activated RAC1. DEF6 also plays a role in Th2 (T helper cells) development and/or activation by interfering with ZAP70 signaling. DEF6 is required for optimal T-cell effector function, lymphocyte homeostasis and the prevention of sytemic autoimmunity. Defects in DEF6 results in spontaneous development of a lupus-like syndrome in aging female mice.
  • Reactivity
    Mouse
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203