Deguelin

MedChem Express

Deguelin [522-17-8]

10

522-17-8

Research Use Only

99.20

C23H22O6

394.42

Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-kappaB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1alpha, COX-2, and NF-kappaB.

O=C1[C@]2([H])[C@](COC3=CC(OC)=C(OC)C=C32)([H])OC4=C5C=CC(C)(C)OC5=CC=C14

-20°C,2°C to 8°C

12352200