Dehydroepiandrosterone sulfate [651-48-9]

MedChem Express

Dehydroepiandrosterone sulfate [651-48-9]

10

651-48-9

Research Use Only

99.93

C19H28O5S

368.49

Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) is a neurosteroid and the main secretion product of the adrenal gland. Dehydroepiandrosterone sulfate has both non-competitive antagonist activity of GABAA receptor and agonist activity of sigma1 receptor. Dehydroepiandrosterone sulfate can partially penetrate the blood-brain barrier, inhibit GABAA receptor-mediated chloride influx, enhance NMDA receptor activity through sigma1 receptors, exert anti-inflammatory, anti-glucocorticoid and antidepressant effects, and increase convulsive sensitivity. Dehydroepiandrosterone sulfate participates in neuroprotection, neurite growth regulation and catecholamine secretion regulation, and can be used in the study of depression, post-traumatic stress disorder (PTSD), Alzheimers disease, etc. Dehydroepiandrosterone sulfate may also be a biomarker for cardiovascular disease mortality, and its concentration is independently and negatively correlated with mortality[1][2][3][4].

C[C@@]12[C@]3([H])[C@](CC=C1C[C@@H](OS(=O)(O)=O)CC2)([H])[C@@]4([H])[C@@](C)(C(CC4)=O)CC3

-20°C,2°C to 8°C

12352200