delta-Secretase inhibitor 11

MedChem Express

delta-Secretase inhibitor 11 [842964-18-5]

10

842964-18-5

Research Use Only

99.35

C10H12N4O2

220.232

delta-Secretase inhibitor 11 (compound 11) is an orally active, potent, BBB-penetrated, non-toxic, selective and specific delta-secretase inhibitor, with an IC50 of 0.7 microM. delta-Secretase inhibitor 11 interacts with both the active site and allosteric site of delta-secretase. delta-Secretase inhibitor 11 attenuates tau and APP (amyloid precursor protein) cleavage. delta-Secretase inhibitor 11 ameliorates synaptic dysfunction and cognitive impairments in tau P301S and 5XFAD transgenic mouse models. delta-Secretase inhibitor 11 can be used for Alzheimers disease research[1].

NC1=CC=C(N2CCOCC2)C3=NON=C31

2°C to 8°C

12352200