Dengue virus NS1 ELISA Antibody Duo

Arigo Biolaboratories

Dengue virus NS1 ELISA Antibody Duo

23

ELISA

Research Use Only

POLY

polyprotein

DENV_gp1, polyprotein gene, polyprotein, RNA-dependent RNA polymerase NS5, anchored capsid protein ancC, capsid protein C, envelope protein E, membrane glycoprotein M, membrane glycoprotein precursor prM, nonstructural protein NS1, nonstructural protein NS2A, nonstructural protein NS2B, nonstructural protein NS3, nonstructural protein NS4A, nonstructural protein NS4B, protein 2K, protein pr

Dengue virus NS1 protein is a nonstructural protein which could be secreted and have been developed as diagnostic biomarker for early detection. There are several forms of NS1 including monomer, dimer, and hexamer during infection. Dimeric NS1 can be anchored to cell membranes with glycosyl-phosphatidylinositol (GPI). Hexameric NS1 can be secreted and detected in patients blood samples (up to 50 microg/mL) or infected cell supernatants (various from ng/mL to microg/mL depend on serotypes and strains). Studies have shown that NS1 could interfere complement activity and prothrombin activation. In addition, NS1 could elicit antibodies which cross-react with host antigens including coagulation factors and molecules expressed in endothelial cells and platelets through molecular mimic.

-20°C

12352203