Denibulin HCl [779356-64-8]

TargetMol Chemicals

Denibulin HCl [779356-64-8]

72

779356-64-8

Chemical

Research Use Only

Denibulin HCl

C18H20ClN5O3S

421.9

Denibulin (MN-029) is a novel vascular-disrupting agent that reversibly inhibits microtubule assembly, resulting in disruption of the cytoskeleton of tumor vascular endothelial cells. The results of preclinical study demonstrated that MN-029 could cause rapid vascular shutdown in solid tumors, dose-dependent secondary tumor cell killing, and effective enhancement of the antitumor effects of radiation and cisplatin chemotherapy.

3 years

Cl.COC(=O)Nc1nc2ccc(Sc3ccc(NC(=O)[C@H](C)N)cc3)cc2[nH]1

-20°C

12352200