DENND1B antibody [N1C1]

GeneTex

DENND1B antibody [N1C1]

9

WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry

Research Use Only

Polyclonal

0.9 mg/ml

Unconjugated

DENND1B

DENN domain containing 1B

C1ORF18; C1orf218; connecdenn 2; DENN domain-containing protein 1B; DENN/MADD domain containing 1B; FAM31B; family with sequence similarity 31, member B

Rabbit

IgG

DENN domain-containing protein 1B

Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM]

-20°C or -80°C,2°C to 8°C

12352203