DETD-35

MedChem Express

DETD-35

9

Research Use Only

C27H24O6

444.48

DETD-35 is an inhibitor of the MEK-ERK, Akt, and STAT3 signaling pathways, which promotes cancer cell apoptosis (Apoptosis) and reduces cancer cell resistance to Vemurafenib (HY-12057). The IC50 values of DETD-35 against wild-type and mutant melanoma cell lines B16-F10, MeWo, SK-MEL-2, A2058c, and A375c are 2.7, 6.0, 3.9, 3.1, and 2.5 microM, respectively. DETD-35 holds promise for research in the field of anti-melanoma therapy[1].

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