Dexpramipexole dihydrochloride

Biorbyt

Dexpramipexole dihydrochloride [104632-27-1]

10

104632-27-1

Research Use Only

C10H19Cl2N3S

284.249

Dexpramipexole 2Hcl(KNS-760704), also known as R-(+)-Pramipexole, is a neuroprotective agent and weak non-ergoline dopamine agonist. IC50 Value:Target: Dopamine ReceptorDexpramipexole has been found to have neuroprotective effects and is being investigated for treatment of amyotrophic lateral sclerosis (ALS). Dexpramipexole reduces mitochondrial reactive oxygen species (ROS) production, inhibits the activation of apoptotic pathways, and increase cell survival in response to a variety of neurotoxins and beta-amyloid neurotoxicity. Compared to the S-(-) isomer, Dexpramipexole has much lower dopamine agonist activity.

Cl.Cl.CCCNC1CC2=C(CC1)N=C(=N)S2

12352200