DFPQ [911678-60-9]

TargetMol Chemicals

DFPQ [911678-60-9]

9

Research Use Only

C20H20F2N4

354.4

DFPQ is a powerful and selective beta-arrestin-biased negative allosteric modulator(NAM) targeting the beta2-adrenergic receptor. It specifically inhibits the interaction of beta-arrestin with beta2AR without altering beta-agonist-induced cAMP production. Additionally, DFPQ reduces functional desensitization of the beta2AR in airway smooth muscle, enhancing beta-agonists capacity to maintain bronchorelaxation and curbing cell migration during prolonged beta-agonist treatment.

FC1=CC=C(C=C1F)NC=2N=C3C=CC=CC3=C(N2)NC4CCCCC4

-20°C

12352200