DFX117 [2125500-60-7]

TargetMol Chemicals

DFX117 [2125500-60-7]

9

Research Use Only

C26H26F2N6O5S

572.58

DFX117 is an orally effective selective inhibitor of PI3Kalpha and c-Met tyrosine kinase (c-Met). This compound inhibits the PI3K/Akt/mTOR pathway and suppresses the proliferation of NCI-H1975, NCI-H1993, and HCC827 cells, with IC50 values ranging from 0.02 to 0.08 microM. Additionally, DFX117 induces cell cycle arrest in the G0/G1 phase and triggers apoptosis (apoptosis) in A549 and NCI-H1975 cells. It also exhibits antitumor activity in mice.

O=C(NCCN1CCOCC1)C2=CN=C3C=CC(=CN32)C=4C=NC(OC)=C(C4)NS(=O)(=O)C5=CC=C(F)C=C5F

-20°C

12352200