DHFR-IN-2 [331942-46-2]

TargetMol Chemicals

DHFR-IN-2 [331942-46-2]

72

Chemical

Research Use Only

DHFR-IN-2

C14H13NO2

227.26

DHFR-IN-2 (compound 4e) is a potent and uncompetitive inhibitor of MtDHFR, with an IC50 of 7 microM. The enzyme dihydrofolate reductase from M. tuberculosis (MtDHFR) holds high unexploited potential as a drug target due to its importance for pathogen survival. DHFR-IN-2 can be used for tuberculosis (TB) research [1].

3 years

C(NC1=CC=CC=C1)C2=CC(C(O)=O)=CC=C2

-20°C

51202000