DHFR-IN-22

MedChem Express

DHFR-IN-22

5

Research Use Only

C22H30N4O4

414.50

DHFR-IN-22 (Compound 8) is a DHFR (Dihydrofolate Reductase) inhibitor belonging to the class of 2,4-diaminopyrimidine compounds. DHFR-IN-22 exhibits significant inhibitory activity against purified DHFR enzyme and major species of nontuberculous mycobacteria (NTM), namely Mycobacterium avium and Mycobacterium abscessus. It shows an IC50 of 1.1 nM and MIC of 1.5 microg/mL against M. abscessus, and an IC50 of 6.3 nM and MIC of 0.1 microg/mL against M. avium. Additionally, it demonstrates an IC50 of 2100 nM against human DHFR. DHFR-IN-22 holds potential for studying novel strategies to combat NTM infections[1].

O=C(O)CCC1=C(OCCCOC2=C(N)N=C(N)N=C2C3CCCCC3)C=CC=C1

12352200