DHX58 Antibody

Cusabio

DHX58 Antibody

20

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

DHX58

DExH-box helicase 58

D11LGP2, D11lgp2e, LGP2, RLR-3, ATP-dependent RNA helicase DHX58, ATP-dependent helicase LGP2, DEXH (Asp-Glu-X-His) box polypeptide 58, RIG-I-like receptor 3, RIG-I-like receptor LGP2, RLR, RNA helicase LGP2, ortholog of mouse D11lgp2, probable ATP-dependent RNA helicase DHX58, probable ATP-dependent helicase LGP2, protein D11Lgp2 homolog

Rabbit

IgG

ATP-dependent RNA helicase DHX58

Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5-triphosphorylated RNA, although it can recognize RNA lacking a 5-triphosphate.

Human, Rat

-20°C or -80°C

41116161