Diclofenac [15307-86-5]

MedChem Express

Diclofenac [15307-86-5]

10

15307-86-5

Research Use Only

99.98

C14H11Cl2NO2

296.15

Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 microM for ovine COX-1 and COX-2, respectively[2]. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

O=C(O)CC1=CC=CC=C1NC2=C(Cl)C=CC=C2Cl

-20°C,2°C to 8°C

12352200