Dicumarol

Biorbyt

Dicumarol [66-76-2]

10

66-76-2

Research Use Only

C19H12O6

336.2949858

Dicoumarol (INN) or dicumarol (USAN) is a naturally occurring anticoagulant that functions as a functional vitamin K depleter (similar to warfarin, a drug that dicoumarol inspired). It is also used in biochemical experiments as an inhibitor of reductases. Like all 4-hydroxycoumarin drugs it is a competitive inhibitor of vitamin K epoxide reductase, an enzyme that recycles vitamin K, thus causing depletion of active vitamin K in blood. This prevents the formation of the active form of prothrombin and several other coagulant enzymes. These compounds are not antagonists of Vitamin K directly-as they are in pharmaceutical uses-but rather promote depletion of vitamin K in bodily tissues allowing vitamin Ks mechanism of action as a potent medication for dicoumarol toxicity. The mechanism of action of Vitamin K along with the toxicity of dicoumarol are measured with the prothrombin time (PT) blood test. (Source: https://en.wikipedia.org/wiki/Dicoumarol).

C1C=CC2C(=C(CC3C(=O)OC4C=CC=CC=4C=3O)C(OC=2C=1)=O)O

12352200