Difluprednate [23674-86-4]

MedChem Express

Difluprednate [23674-86-4]

10

23674-86-4

Research Use Only

99.64

C27H34F2O7

508.55

Difluprednate is a glucocorticoid receptor (GC receptor) agonist with a Ki of 0.78 nM. Difluprednates active metabolite 21-deacetylated difluprednate (DFB) is a competitive agonist of GC receptors with a Ki of 0.061 nM. Difluprednate binds to GC receptors through metabolism to DFB, regulating the transcription of inflammatory mediator genes, thereby exerting anti-inflammatory activity. Difluprednate can be used for research related to ocular inflammation, such as postoperative inflammation, anterior uveitis, etc[1][2].

O=C([C@]([C@]12C)(CC[C@@]1([H])[C@@](C[C@H](F)C3=CC4=O)([H])[C@@](F)([C@]3(C=C4)C)[C@@H](O)C2)OC(CCC)=O)COC(C)=O

-20°C,2°C to 8°C

12352200