Dihydroeponemycin

MedChem Express

Dihydroeponemycin [126463-64-7]

10

126463-64-7

Research Use Only

C20H36N2O6

400.51

Dihydroeponemycin, an analogue of the antitumor and antiangiogenic natural product eponemycin, selectively targets the 20S proteasome . Dihydroeponemycin covalently modifies a subset of catalytic proteasomal subunits, binding preferentially to the IFN-gamma-inducible subunits LMP2 and LMP7. Dihydroeponemycin-mediated proteasome inhibition induces a spindle-like cellular morphological change and apoptosis [1] .

CC(C)CCCCC(N[C@@H](CO)C(N[C@@H](CC(C)C)C([C@]1(CO1)CO)=O)=O)=O

12352200