Dihydrostreptomycin

MedChem Express

Dihydrostreptomycin [128-46-1]

5

128-46-1

Research Use Only

C23H45N7O12

611.64

Dihydrostreptomycin (DHSM) is an antibiotic that exhibits resistance to penicillin in strains of Pseudomonas lachrymans. Studies have shown that these strains can inactivate DHSM using a cell-free system in the presence of disodium adenosine triphosphate. The inactivated DHSM can be regenerated by alkaline phosphatase but not by phosphodiesterase. The structure of the inactivated DHSM has been determined by methods such as proton magnetic resonance imaging, and it was found that the hydroxyl group at the C-3 position of DHSM in its chemical structure is phosphorylated by the enzyme. Therefore, the study suggests that ATP:aminoglycoside 3-phosphotransferase plays a role in DHSM resistance in Pseudomonas lachrymans N-7641 [1] .

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