Diphyllin [22055-22-7]
HY-N2532
CAS Number22055-22-7
Product group Chemicals
Estimated Purity99.90
Molecular Weight380.35
Overview
- SupplierMedChem Express
- Product NameDiphyllin [22055-22-7]
- Delivery Days Customer9
- CAS Number22055-22-7
- CertificationResearch Use Only
- Estimated Purity99.90
- Molecular FormulaC21H16O7
- Molecular Weight380.35
- Scientific DescriptionDiphyllin is an orally active V-ATPase inhibitor (IC50=17 nM) and HIV-1 inhibitor (IC50=0.38 microM). Diphyllin blocks the acidification of osteoclast lysosomes and bone resorption lacunas (IC50=0.6 nM for acid influx inhibition), thereby inhibiting bone resorption. Diphyllin can effectively inhibit osteoclast-mediated bone resorption and has no effect on osteoblastic bone formation. Diphyllin can be used in the research of bone metabolism-related diseases and has the potential to inhibit diseases related to excessive bone resorption[1][2][3][4].
- SMILESO=C1OCC2=C(O)C3=CC(OC)=C(OC)C=C3C(C4=CC=C(OCO5)C5=C4)=C12
- Storage Instruction-20°C
- UNSPSC12352200
MSDS
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