Dipraglurant [872363-17-2]

MedChem Express

Dipraglurant [872363-17-2]

10

872363-17-2

Research Use Only

99.90

C16H12FN3

265.29

Dipraglurant (ADX48621) is a potent, selective, orally active and brain penetrant mGluR5 negative allosteric modulator (NAM), with an IC50 of 21 nM. Dipraglurant can reduce Levodopa-induced dyskinesia (LID) in vivo[1][2]. Dipraglurant is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

FC1=CN2C(C=C1)=NC(CCC#CC3=NC=CC=C3)=C2

-20°C,2°C to 8°C

12131703