DIS3L2 Antibody

Cusabio

DIS3L2 Antibody

20

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

DIS3L2

DIS3 like 3'-5' exoribonuclease 2

FAM6A, PRLMNS, hDIS3L2, DIS3-like exonuclease 2, DIS3 mitotic control homolog-like 2, family with sequence similarity 6, member A

Rabbit

IgG

DIS3-like exonuclease 2

3-5-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3 end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.

Human

-20°C or -80°C

41116161