DISC1 Antibody, Biotin conjugated

Cusabio

DISC1 Antibody, Biotin conjugated

20

ELISA

Research Use Only

Polyclonal

Biotin

DISC1

DISC1 scaffold protein

C1orf136; disrupted in schizophrenia 1 protein; SCZD9

Rabbit

IgG

Disrupted in schizophrenia 1 protein

Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.

Human

-20°C or -80°C

12352203