Western Blot Positive WB detected in: SH-SY5Y whole cell lysate, Hela whole cell lysate All lanes: DISC1 antibody at 2ug/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 94, 92, 74, 39, 83, 63, 61, 76, 73, 38, 22 kDa Observed band size: 94, 92, 38 kDa
DISC1 Antibody
CSB-PA889093LA01HU
ApplicationsImmunoFluorescence, Western Blot, ELISA
Product group Antibodies
ReactivityHuman
TargetDISC1
Overview
- SupplierCusabio
- Product NameDISC1 Antibody
- Delivery Days Customer20
- ApplicationsImmunoFluorescence, Western Blot, ELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID27185
- Target nameDISC1
- Target descriptionDISC1 scaffold protein
- Target synonymsC1orf136; disrupted in schizophrenia 1 protein; SCZD9
- HostRabbit
- IsotypeIgG
- Protein IDQ9NRI5
- Protein NameDisrupted in schizophrenia 1 protein
- Scientific DescriptionInvolved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203