DL-TBOA

MedChem Express

DL-TBOA [205309-81-5]

10

205309-81-5

Research Use Only

99.60

C11H13NO5

239.23

DL-TBOA is a potent non-transportable inhibitor of excitatory amino acid transporters with IC 50 s of 70 microM, 6 microM and 6 microM for excitatory amino acid transporter-1 (EAAT1) , EAAT2 and EAAT3 , respectively. DL-TBOA inhibits the uptake of [ 14 C]glutamate in COS-1 cells expressing the human EAAT1 and EAAT2 with K i valuesof 42 microM and 5.7 microM, respectively. DL-TBOA blocks EAAT4 and EAAT5 in a competitive manner with K i values of 4.4 microM and 3.2 microM, respectively [1] [2] [3] .

OC([C@@H](N)[C@@H](C(O)=O)OCC1=CC=CC=C1)=O

-20°C,2°C to 8°C

12352200