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DL-TBOA (ammonium)

HY-107522B
MedChem Express
CAS Number2093503-71-8
Product group Chemicals
Molecular Weight256.26
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Overview

  • Supplier
    MedChem Express
  • Product Name
    DL-TBOA (ammonium) [2093503-71-8]
  • Delivery Days Customer
    10
  • CAS Number
    2093503-71-8
  • Certification
    Research Use Only
  • Molecular Formula
    C11H16N2O5
  • Molecular Weight
    256.26
  • Scientific Description
    DL-TBOA ammonium is a potent non-transportable inhibitor of excitatory amino acid transporters with IC 50 s of 70 microM, 6 microM and 6 microM for excitatory amino acid transporter-1 (EAAT1) , EAAT2 and EAAT3 , respectively. DL-TBOA ammonium inhibits the uptake of [ 14 C]glutamate in COS-1 cells expressing the human EAAT1 and EAAT2 with K i valuesof 42 microM and 5.7 microM, respectively. DL-TBOA ammonium blocks EAAT4 and EAAT5 in a competitive manner with K i values of 4.4 microM and 3.2 microM, respectively [1] [2] [3] .
  • SMILES
    OC([C@@H](N)[C@@H](C(O)=O)OCC1=CC=CC=C1)=O.N
  • UNSPSC
    12352200