DL-TBOA (ammonium) [2093503-71-8]

MedChem Express

DL-TBOA (ammonium) [2093503-71-8]

10

2093503-71-8

Research Use Only

C11H16N2O5

256.26

DL-TBOA ammonium is a potent non-transportable inhibitor of excitatory amino acid transporters with IC50s of 70 microM, 6 microM and 6 microM for excitatory amino acid transporter-1 (EAAT1), EAAT2 and EAAT3, respectively. DL-TBOA ammonium inhibits the uptake of [14C]glutamate in COS-1 cells expressing the human EAAT1 and EAAT2 with Ki valuesof 42 microM and 5.7 microM, respectively. DL-TBOA ammonium blocks EAAT4 and EAAT5 in a competitive manner with Ki values of 4.4 microM and 3.2 microM, respectively[1][2][3].

OC([C@@H](N)[C@@H](C(O)=O)OCC1=CC=CC=C1)=O.N

12352200