DL-threo-PPMP

MedChem Express

DL-threo-PPMP [149022-18-4]

5

149022-18-4

Research Use Only

C29H50N2O3

474.72

DL-threo-PPMP is an inhibitor of sphingosine synthetase in Plasmodium falciparum. DL-threo-PPMP inhibits the activity of sphingosine synthetase by mimicking the substrate sphingosine. This inhibition leads to a rapid decrease in the activity of sensitive sphingosine synthetase, selectively destroying the interconnected tubular network of TVMs in the host cell cytoplasm, and this inhibition also blocks the proliferation of Plasmodium falciparum. DL-threo-PPMP can be used for the study of Plasmodium biology and the search for new antimalarial strategies[1].

O=C(N[C@@H]([C@@H](C1=CC=CC=C1)O)CN2CCOCC2)CCCCCCCCCCCCCCC

12352200