Western Blot analysis of 231, A431, Raji, Jurkat and HepG2 cell using HSP40-4 Polyclonal Antibody at dilution of 1:500
Western Blot analysis of 231, A431, Raji, Jurkat and HepG2 cell using HSP40-4 Polyclonal Antibody at dilution of 1:500
DNAJA1 Polyclonal Antibody
E-AB-15115
Product group Antibodies
Overview
- SupplierElabscience
- Product NameDNAJA1 Polyclonal Antibody
- Delivery Days Customer12
- Applications SupplierELISA WB IHC
- CertificationResearch Use Only
- Concentration0.2mg/ml
- Scientific DescriptionDnaJ-like proteins interact with HSP 70 molecular chaperones and function to facilitate protein folding and mitochondrial protein import. HSP 40-4, also known as HDJ2, is the human DnaJ homolog that functions as a co-chaperone with a cysteine-rich zinc finger domain. The cellular redox enzyme thioredoxin interacts with HSP 40-4, and oxidation and reduction reversibly regulate HSP 40-4 function in response to the changing redox states of the cell. The zinc finger domain of HSP 40-4 may act as a redox sensor of chaperone-mediated protein-folding machinery, since HSP 40-4 inactivation leads to the oxidation of cysteine thiols and a simultaneous release of coordinated zinc. Loss of the HSP 40-4 protein may be linked to severe defects in spermatogenesis that involve aberrant androgen signaling.
- UNSPSC12352203