DNAJC2 Antibody

Cusabio

DNAJC2 Antibody

20

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

DNAJC2

DnaJ heat shock protein family (Hsp40) member C2

MPHOSPH11, MPP11, ZRF1, ZUO1, dnaJ homolog subfamily C member 2, DnaJ (Hsp40) homolog, subfamily C, member 2, M-phase phosphoprotein 11, zuotin-related factor 1

Rabbit

IgG

DnaJ homolog subfamily C member 2

Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at Lys-119 (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5-GTCAAGC-3.

Human

-20°C or -80°C

41116161