DNL343 [2278265-85-1]

TargetMol Chemicals

DNL343 [2278265-85-1]

72

Chemical

Research Use Only

DNL343

C20H19ClF3N3O4

457.83

DNL343 is a selective and potent eIF2B activator that crosses the blood-brain barrier and inhibits the assembly of stress granules (SGs) induced by the C9ORF72 dipeptide repeats. DNL343 may be useful in the study of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS).

3 years

N(C(COC1=CC=C(Cl)C=C1)=O)C23CC(C2)(C3)C=4OC(=NN4)[C@@H]5C[C@H](OC(F)(F)F)C5

-20°C

12352200