DNL343

MedChem Express

DNL343

5

Research Use Only

99.94

C20H19ClF3N3O4

457.83

DNL343 is a potent, selective, orally active and brain-penetrant activator of eukaryotic initiation factor eIF2B . DNL343 inhibits the activity of the integrated stress response (ISR) in the central nervous system (CNS) and reverses neurodegeneration and neuroinflammation. DNL343 also prevents motor dysfunction and premature death in eIF2B loss-of-function (LOF) mutant mice. DNL343 can be used in the study of neurodegenerative diseases [1] [2] [3] .

ClC(C=C1)=CC=C1OCC(NC23CC(C3)(C4=NN=C([C@@H]5C[C@@H](C5)OC(F)(F)F)O4)C2)=O

-20°C,2°C to 8°C

12352200