Dopamine D3 receptor antagonist-3

MedChem Express

Dopamine D3 receptor antagonist-3

999

Research Use Only

C18H17ClF5N3O3S

485.86

Dopamine D3 receptor antagonist-3 is a D3 dopamine receptor (D3R)-selective positive allosteric modulator (PAM)-antagonist that can cross the blood-brain barrier. Dopamine D3 receptor antagonist-3 exhibits antagonist activity in the D3R-mediated beta-arrestin recruitment assay with an IC50 and a Kb of 2.5 microM and 0.49 microM. amine D3 receptor antagonist-3 is also an antagonist in the D3R-mediated Go-BRET assay with an IC50 of 0.34 microM. Dopamine D3 receptor antagonist-3 can be used for the study of neuropsychiatric disorders, including substance use disorder[1].

ClC(C=C1NS(C(C(C(N(C2)CCC2(F)F)=O)=C3C)=C(N3)C)(=O)=O)=C(C=C1)C(F)(F)F

12352200