Dot1L-IN-1 [2088518-50-5]

MedChem Express

Dot1L-IN-1 [2088518-50-5]

10

2088518-50-5

Research Use Only

C32H36ClN9O2S

646.21

Dot1L-IN-1 is a highly potent and selective Dot1L inhibitor with a Ki of 2 pM and an IC50 of 50=3 nM), as well as the activity of the HoxA9 promoter (IC50=17 nM) in HeLa and Molm-13 cells, respectively[1].

CC1=NC=CC=C1C2=C(Cl)SC3=CC=C(NC(NCC(NCCCN(C)[C@@H]4CCCN(C5=C(C=CN6)C6=NC=N5)C4)=O)=O)C=C32

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