Dot1L-IN-1 TFA

MedChem Express

Dot1L-IN-1 TFA

10

Research Use Only

98.56%

C34H37ClF3N9O4S

760.23

Dot1L-IN-1 TFA is a highly potent and selective Dot1L inhibitor with a Ki of 2 pM and an IC50 of 50=3 nM), as well as the activity of the HoxA9 promoter (IC50=17 nM) in HeLa and Molm-13 cells, respectively.

CC1=NC=CC=C1C2=C(Cl)SC3=CC=C(NC(NCC(NCCCN(C)[C@@H]4CCCN(C5=C(C=CN6)C6=NC=N5)C4)=O)=O)C=C32.OC(C(F)(F)F)=O

2°C to 8°C,-20°C,-80°C

12352200