Dothiepin [113-53-1]

MedChem Express

Dothiepin [113-53-1]

14

113-53-1

Research Use Only

98.22

C19H21NS

295.44

Dothiepin (Dosulepin; Dothep) is an antidepressant agent with sedative/anxiolytic activity. Dothiepin is an inhibitor preferring of noradrenaline uptake than serotonin uptake. Dothiepin facilitates noradrenergic neurotransmission via inhibiting the neuronal uptake. Dothiepin is also an antagonist of histamine H1-receptor without cardiotoxicity. Dothiepin exhibits significant analgesic activity in psychogenic facial pain, idiopathic fibromyalgia syndrome or rheumatoid arthritis[1].

CN(C)CC/C=C1C2=CC=CC=C2SCC3=CC=CC=C/13

-20°C,2°C to 8°C

12352200