Dovitinib

MedChem Express

Dovitinib [405169-16-6]

10

405169-16-6

Research Use Only

99.88

C21H21FN6O

392.43

Dovitinib (CHIR-258) is an orally active, potent multi-targeted tyrosine kinase (RTK) inhibitor with IC 50 s of 1, 2, 36, 8/9, 10/13/8, 27/210 nM for FLT3 , c-Kit , CSF-1R , FGFR1/FGFR3 , VEGFR1/VEGFR2/VEGFR3 and PDGFRalpha/PDGFRbeta , respectively. Dovitinib has potent antitumor activity [1] [2] .

O=C1NC(C=CC=C2F)=C2C(N)=C1C3=NC4=CC=C(N5CCN(C)CC5)C=C4N3

-20°C,2°C to 8°C

12352200