Doxapram [309-29-5]

MedChem Express

Doxapram [309-29-5]

10

309-29-5

Research Use Only

99.70

h317, h319

C24H30N2O2

378.51

Doxapram is a respiratory stimulant. Doxapram increases breathing rate and depth by acting on the brains respiratory centers and peripheral chemoreceptors. Doxapram inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50s of 410 nM, 37 microM, 9 microM, respectively. Doxapram inhibits the Ca2+-activated potassium current (IC50 ~ 13 microM) and Ca2+-independent potassium current (IC50 ~ 20 microM) in type I cells of the carotid body. Doxapram significantly prolongs the effective refractory period of the atrium and has an anti-arrhythmic effect. Doxapram can be used for the study of respiratory depression such as post-anesthesia respiratory depression, chronic obstructive pulmonary disease and apnea of prematurity[1][2][3][4][5][6].

O=C1N(CC)CC(CCN2CCOCC2)C1(C3=CC=CC=C3)C4=CC=CC=C4

-20°C,2°C to 8°C

12352200