Doxazosin (hydrochloride) [70918-01-3]

MedChem Express

Doxazosin (hydrochloride) [70918-01-3]

9

70918-01-3

Research Use Only

C23H26ClN5O5

487.94

Doxazosin hydrochloride (UK 33274 hydrochloride) is a compound used to inhibit hypertension and prostate hyperplasia, with activity that inhibits postsynaptic alpha1-adrenoceptors on vascular smooth muscle. Doxazosin hydrochloride can cause vasodilation, thereby reducing peripheral vascular resistance. Doxazosin hydrochloride was found to inhibit the proliferation and migration of hepatic stellate cells in a mouse liver fibrosis model. Doxazosin hydrochloride regulates fibrosis, autophagy, and apoptosis of hepatic stellate cells by activating the PI3K/Akt/mTOR signaling pathway. Doxazosin hydrochloride also blocks autophagic flux and induces apoptosis of hepatic stellate cells[1].

O=C(C1OC2=C(OC1)C=CC=C2)N3CCN(CC3)C4=NC5=C(C=C(C(OC)=C5)OC)C(N)=N4.Cl

12352200