DR6 peptide

GeneTex

DR6 peptide

9

The peptide is used for blocking the activity of DR6 (GTX28417). Incubatingthe peptide with equal volume of antibody for 30 min at 37C usually completely blocks theantibody activity in Western blotting.

Neutralisation/Blocking

Research Use Only

0.20 mg/ml

Unconjugated

TNFRSF21

TNF receptor superfamily member 21

BM-018, CD358, DR6, tumor necrosis factor receptor superfamily member 21, TNFR-related death receptor 6, death receptor 6

Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor 6. Like TNFR1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK. DR6 is widely expressed inhuman tissues and cell lines. The ligand for DR6 hasnot been identified.

-20°C

41116100

Human