DS18561882

MedChem Express

DS18561882 [2227149-22-4]

10

2227149-22-4

Research Use Only

99.87

C28H31F3N4O6S

608.63

DS18561882 is a highly potent, isozyme-selective methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor with an IC50 value of 0.0063 microM. DS18561882 also has inhibitory effect on MTHFD1 (IC50=0.57 microM). DS18561882 exhibits a good oral pharmacokinetic profile[1].

CS(=O)(NC1=CC=C(C(N2CCC(C3=CC=C(N4C[C@H](C)N(C)CC4)C(C)=C3O5)=C(C5=O)C2)=O)C=C1OC(F)(F)F)=O

2°C to 8°C

12352200