DTHIB

MedChem Express

DTHIB [897326-30-6]

10

897326-30-6

Research Use Only

99.58

C13H9ClFN3O3

309.68

DTHIB is a direct and selective heat shock factor 1 (HSF1) inhibitor with a K d of 160 nM for DTHIB binding to the HSF1 DNA binding domain (DBD) . DTHIB inhibits HSF1 cancer gene signature (HSF1 CaSig) and selectively stimulates degradation of nuclear HSF1 . DTHIB has potently anticancer activities and can be used for prostate cancer research [1] .

O=C(NC1=CC=C(F)C=C1)NC2=CC=C(Cl)C([N+]([O-])=O)=C2

-20°C,2°C to 8°C

12352200