DUSP14 antibody [C2C3], C-term

GeneTex

DUSP14 antibody [C2C3], C-term

9

Western Blot

Research Use Only

Polyclonal

2 mg/ml

Unconjugated

DUSP14

dual specificity phosphatase 14

dual specificity protein phosphatase 14; MAP kinase phosphatase 6; mitogen-activated protein kinase phosphatase 6; MKP-1-like protein tyrosine phosphatase; MKP6; MKP-6; MKP-L

Rabbit

IgG

In addition to antigen recognition by the T-cell receptor, T-cell activation requires a second signal from a costimulatory receptor, such as CD28 (MIM 186760), which interacts with B7-1 (CD80; MIM 112203) and B7-2 (CD86; MIM 601020) ligands on antigen-presenting cells. CD28 costimulation induces transcription of interleukin-2 (IL2; MIM 147680) and stabilizes newly synthesized IL2 through the activation of mitogen-activated protein kinases (MAPKs), such as ERK (e.g., MAP2K4; MIM 601335) and JNK (see MIM 601158), and the subsequent creation of AP1 transcription factor (see MIM 165160). DUSP14 is a negative regulator of CD28 signaling.[supplied by OMIM]

Human

2°C to 8°C,-20°C or -80°C

12352203