ProductsBack/DUSP26 antibody [N1C1]

DUSP26 antibody [N1C1]

Name: DUSP26 antibody [N1C1]
SKU: GTX109283_G10
Availability: BackOrder

GTX109283

ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry

Product group Antibodies

TargetDUSP26

Overview

Supplier
GeneTex
Product Name
DUSP26 antibody [N1C1]
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1.52 mg/ml
Conjugate
Unconjugated
Gene ID78986
Target name
DUSP26
Target description
dual specificity phosphatase 26
Target synonyms
DSP-4, DUSP24, LDP-4, LDP4, MKP-8, MKP8, NATA1, NEAP, SKRP3, dual specificity protein phosphatase 26, MAP kinase phosphatase 8, Novel amplified gene in thyroid anaplastic cancer, dual specificity phosphatase 26 (putative), dual specificity phosphatase SKRP3, low-molecular-mass dual-specificity phosphatase 4, mitogen-activated protein kinase phosphatase 8, neuroendocrine-associated phosphatase
Host
Rabbit
Isotype
IgG
Protein IDQ9BV47
Protein Name
Dual specificity protein phosphatase 26
Scientific Description
Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Kikuchi S, Wada A, Kamihara Y, et al. DPP8 Selective Inhibitor Tominostat as a Novel and Broad-Spectrum Anticancer Agent against Hematological Malignancies. Cells. 2023,12(7). doi: 10.3390/cells12071100
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Eroglu B, Jin X, Deane S, et al. Dusp26 phosphatase regulates mitochondrial respiration and oxidative stress and protects neuronal cell death. Cell Mol Life Sci. 2022,79(4):198. doi: 10.1007/s00018-022-04162-z
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Qiao X, Zhu Y, Dang W, et al. Dual-specificity phosphatase 15 (DUSP15) in the nucleus accumbens is a novel negative regulator of morphine-associated contextual memory. Addict Biol. 2021,26(1):e12884. doi: 10.1111/adb.12884
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Yang CH, Yeh YJ, Wang JY, et al. NEAP/DUSP26 suppresses receptor tyrosine kinases and regulates neuronal development in zebrafish. Sci Rep. 2017,7(1):5241. doi: 10.1038/s41598-017-05584-7
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Kim H, Lee HJ, Oh Y, et al. The DUSP26 phosphatase activator adenylate kinase 2 regulates FADD phosphorylation and cell growth. Nat Commun. 2014,5:3351. doi: 10.1038/ncomms4351
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