Dyrk1A-IN-4 [2091883-59-7]

MedChem Express

Dyrk1A-IN-4 [2091883-59-7]

10

2091883-59-7

Research Use Only

99.90

C14H13F3N6

322.29

Dyrk1A-IN-4 is a potent and orally active Dyrk1A inhibitor. Dyrk1A-IN-4 exhibits IC50s against DYRK1A and DYRK2 of 2 nM and 6 nM. Dyrk1A-IN-4 exhibits the inhibition of the DYRK1A pSer520 autophosphorylation in U2OS cells with an IC50 of 28 nM. Dyrk1A-IN-4 can be used for the studies of ovarian adenocarcinoma, neuroblastoma and cervical squamous cell carcinoma[1].

FC(F)(CN1C2=C(N=C1C)C=CC(C3=CC(N)=NC(N)=C3)=N2)F

-20°C,2°C to 8°C

12131703