DYRKi [1640364-04-0]
HY-119607
CAS Number1640364-04-0
Product group Chemicals
Molecular Weight430.40
Overview
- SupplierMedChem Express
- Product NameDYRKi [1640364-04-0]
- Delivery Days Customer9
- CAS Number1640364-04-0
- CertificationResearch Use Only
- Molecular FormulaC20H13F3N4O2S
- Molecular Weight430.40
- Scientific DescriptionDYRKi is an inhibitor of DYRK1 and DYRK1B with IC50 values of 3.7 microM and 90 nM, respectively, which is used as a potent antagonist of Hh/Gli signaling. DYRKi impairs SMO-dependent and SMO-independent oncogenic GLI activity in human medulloblastoma cells. DYRKi is promising for research of HH/GLI-associated cancers[1].
- SMILESO=C(NC1=NC2=CC(C(F)(F)F)=CC=C2N1)C3=CSC(C4=CC=C5OCCC5=C4)=N3
- UNSPSC12352200