(E)-Ajoene [92284-99-6]

TargetMol Chemicals

(E)-Ajoene [92284-99-6]

44

92284-99-6

Research Use Only

(E)-Ajoene

C9H14OS3

234.39

(E)-Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities.1,2,3,4It is active against Gram-positive and Gram-negative bacteria (MICs = 10-250 and 150->500 microg/ml, respectively) and fungi (MICs = 15-50 microg/ml).1(E)-Ajoene inhibits proliferation of a variety of cancer cells, including MDA-MB-231 breast, HeLa cervical, and WHCO1 esophageal cancer cells (IC50s = 18.6, 61, and 39.2 microM, respectively).2It also inhibits human glutathione reductase andT. cruzitrypanothione reductase when used at a concentration of 200 microM.3(E)-Ajoene (25 mg/kg) is neuroprotective in a gerbil model of ischemia-reperfusion injury, reducing reactive astrocytosis and microgliosis in the hippocampal CA1 region.4

3 years

C=CCSS\C=C\CS(=O)CC=C

-20°C

12352200