(E)-KN-93 (phosphate) [1188890-41-6]

MedChem Express

(E)-KN-93 (phosphate) [1188890-41-6]

5

1188890-41-6

Research Use Only

99.85

C26H32ClN2O8PS

599.03

(E)-KN-93 phosphate is an inhibitor for Ca2+/calmodulin-dependent protein kinase II (CaMK II) with IC50 of 9 microM and 3 microM, for CaMKIIdelta monomer and CaMKIIdelta dodecamer. (E)-KN-93 phosphate binds competitively with Ca2+/CaM, and disrupts their interaction with CaMK II, and thus inhibits the CaMK II activation[1].

O=P(O)(O)O.O=S(N(C1=C(C=CC=C1)CN(C)C/C=C/C2=CC=C(C=C2)Cl)CCO)(C3=CC=C(C=C3)OC)=O

RT

12352200