(E)-SI-2 [380537-35-9]

TargetMol Chemicals

(E)-SI-2 [380537-35-9]

4

380537-35-9

Chemical

Research Use Only

(E)-SI-2

C15H15N5

265.31

(E)-SI-2 is a potent small-molecule inhibitor of steroid receptor coactivator-3 (SRC-3 or AIB1) that can selectively inhibit the intrinsic transcriptional activities of SRC-3, also inhibits SRC-1 and SRC-2. It selectively reduces cellular protein levels of SRC-3, but not that of CARM-1, blocks MDA-MB-468 cell growth with an IC50 value of 3.4 nM, but spares normal cells.

3 years

CN1C=2C(N=C1N/N=C(\C)/C3=CC=CC=N3)=CC=CC2

-20°C

12352200